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doi: 10.1038/nrc1014 2 ParkJREggertACaronH

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This can be particularly important during supply shortages or in clinics managing frequent medication preparation

Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver